Grand Theft Auto V (GTA V) is an open-world action-adventure game developed by Rockstar North and published by Rockstar Games. The game is set in the fictional city of Los Santos, and it allows players to take on the role of three different characters, each with their own unique storylines and missions.

1. Start by creating a new game and choosing one of the three characters: Michael, Franklin, or Trevor.

2. Complete the tutorial missions to get a feel for the controls and gameplay mechanics.

3. As you progress through the game, you will be able to complete various missions, heists, and side activities to earn money and advance the story.

4. You can also explore the open world of Los Santos, which is filled with various landmarks, businesses, and activities.

5. Use your earnings to purchase properties, vehicles, and weapons, which will help you in future missions and activities.

6. Take on various side activities, such as street racing, tennis, and golf, to earn extra money and experience.

7. You can also commit crimes and cause chaos in the city, but be aware that law enforcement will come after you.

8. As you progress through the game, you will unlock new abilities and upgrades, such as the ability to fly planes and helicopters.

9. The game also includes a multiplayer mode called GTA Online, where you can join a crew, participate in heists and activities, and compete against other players.

That's a general guide for how to play Grand Theft Auto V, but keep in mind that the game is vast and offers a lot of content and activities, so there are many more things to discover and enjoy.

 Here is a general overview of the main missions in the game, grouped by character:

Michael:

• Prologue: Michael's first mission is to rob a bank with his old crew.

• Father/Son: Michael must reconnect with his family and help his son, Jimmy, with his problems.

• The Long Stretch: Michael, Franklin and Trevor pull off a big heist together.

• Marriage Counseling: Michael's wife Amanda is cheating on him, and he must deal with the consequences.

• Friend Request: Michael helps Franklin with a problem involving a mutual friend.

• Daddy's Little Girl: Michael must save his daughter Tracey from a dangerous situation.

 Prologue:

1. Meet with your old crew at the meeting spot in Vinewood Hills.

2. Drive to the bank in Downtown Vinewood.

3. Enter the bank and hold up the tellers for cash.

4. Escape the police and return to the meeting spot.

Father/Son:

1. Meet with your son, Jimmy, at his house in Vinewood Hills.

2. Listen to Jimmy's problems and offer advice and help.

3. Complete various missions to help Jimmy with his issues, such as stealing cars and completing drug deals.

4. Help Jimmy strengthen his relationship with his family.

The Long Stretch:

1. Meet with Franklin and Trevor at the planning location in Vinewood Hills.

2. Plan and execute the heist together.

3. Escape the police and divide the loot among the team.

Marriage Counseling:

1. Confront Amanda about her infidelity.

2. Choose how to react to the situation, whether it be trying to save the marriage or ending it.

3. Complete missions related to the outcome of the confrontation with Amanda.

Friend Request:

1. Meet with Franklin to discuss the mutual friend's problem.

2. Help Franklin gather information and plan a solution.

3. Complete missions to assist Franklin in resolving the issue.

Daddy's Little Girl:

1. Meet with Tracey at her location in Vinewood Hills.

2. Learn about the danger Tracey is in and devise a plan to save her.

3. Complete missions to rescue Tracey and ensure her safety.

Franklin:

• Franklin and Lamar: Franklin helps his friend Lamar to recover a stolen car.

• Repossession: Franklin repossesses cars for an unscrupulous dealer.

• Chop: Franklin helps his friend Lamar to train a dog.

• Complications: Franklin helps Michael with a problem involving a mutual friend.

• Dead Man Walking: Franklin assists Michael in a dangerous situation.

Franklin and Lamar:

1. Meet Lamar at his house in Forum Drive.

2. Drive to the location where Lamar's car was stolen.

3. Recover the stolen car and fend off the thieves.

4. Return the car to Lamar.

Repossession:

1. Meet with the unscrupulous dealer in the parking lot of Los Santos Customs.

2. Receive a list of cars to repossess.

3. Drive to the locations of the cars and repossess them.

4. Return the repossessed cars to the dealer.

Chop:

1. Meet Lamar at his house in Forum Drive.

2. Train Chop, Lamar's dog, to follow commands and find specific items.

3. Complete various missions and challenges to improve Chop's abilities.

4. Help Lamar use Chop to assist in criminal activities.

Complications:

1. Meet with Michael to discuss the problem involving a mutual friend.

2. Help Michael gather information and plan a solution.

3. Complete missions to assist Michael in resolving the issue.

Dead Man Walking:

1. Meet with Michael at the location of the dangerous situation.

2. Help Michael escape the danger and fend off enemies.

3. Complete missions to ensure Michael's safety and resolve the situation.

Trevor:

• Nervous Ron: Trevor helps his friend Ron with a problem involving a stolen drug shipment.

• Mr. Philips: Trevor and his partner, Brad, must deal with a problem involving a stolen drug shipment.

• The Third Way: Trevor helps Michael and Franklin with a problem involving a mutual friend.

Nervous Ron:

1. Meet Ron at his trailer in Sandy Shores.

2. Learn about the problem involving a stolen drug shipment.

3. Gather information and devise a plan to retrieve the stolen drugs.

4. Complete missions to recover the stolen drugs and confront those responsible.

Mr. Philips:

1. Meet Brad at his trailer in Sandy Shores.

2. Learn about the problem involving a stolen drug shipment.

3. Gather information and devise a plan to retrieve the stolen drugs.

4. Complete missions with Brad to recover the stolen drugs and confront those responsible.

The Third Way:

1. Meet with Michael and Franklin at the location of the problem involving a mutual friend.

2. Help Michael and Franklin gather information and devise a plan to resolve the issue.

3. Complete missions with Michael and Franklin to assist them in resolving the issue.

4. Choose to either help Michael and Franklin or to betray them and pursue your own agenda.

Keep in mind that these are just the main missions, throughout the game there are many other side missions and activities that you can participate in, such as street racing, tennis, golf, and more.

It is also worth noting that the game has multiple endings depending on the choices you make during the game and how you complete the mission, so the gameplay experience may be different for each player.